Davunetide vs hGHRH(1-37)OH
Head-to-head comparison of Davunetide (Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ)) and hGHRH(1-37)OH (Human growth hormone-releasing factor (1-37) hydroxyl) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Davunetide | hGHRH(1-37)OH |
|---|---|---|
| Category | Cognitive Enhancement | Growth Hormone |
| Full Name | Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ) | Human growth hormone-releasing factor (1-37) hydroxyl |
| Molecular Weight | 796.9 Da | N/A |
| Half-Life | short; minutes to low hours | 5-20 minutes |
| Amino Acids | 8 | 37 |
| Typical Dose | 1-10 mg/day research range | 1-2 mcg/kg |
| Route | Intranasal | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 60 |
| Research Status | Clinical/Pre-clinical | Clinical Research |
Davunetide Benefits
- ✓neuroprotection
- ✓microtubule support
- ✓attention support
- ✓memory preservation
hGHRH(1-37)OH Benefits
- ✓GH release studies
- ✓minimal-sequence mapping
- ✓receptor pharmacology
- ✓peptide stability research
Davunetide Dosing
intranasal research dosing|1-10 mg per dose in trials/preclinical work|once or twice daily
hGHRH(1-37)OH Dosing
1-2 mcg/kg SC or IV bolus|acute stimulation with serial GH assays|short-course research administration with biomarker monitoring
Davunetide Side Effects
- ⚠nasal irritation
- ⚠headache
- ⚠limited efficacy in late-stage trials
hGHRH(1-37)OH Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient fatigue
Research Overview
Davunetide
Preclinical work showed davunetide can protect neurons, preserve synaptic structure, and improve performance in memory tasks. Human trials largely focused on neurodegenerative disease outcomes rather than stand-alone nootropic use, but the literature supports CNS activity.
hGHRH(1-37)OH
Human GHRF(1-37)OH has appeared in studies examining how loss of C-terminal residues affects biological activity at the GHRH receptor. It is often used alongside other fragments to define structure-activity relationships within the GHRH family.
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