MK-677 vs 5-Amino-1MQ
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and 5-Amino-1MQ (5-Amino-1-methylquinolinium) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | 5-Amino-1MQ |
|---|---|---|
| Category | Growth Hormone | Weight Management |
| Full Name | Ibutamoren Mesylate (MK-677) | 5-Amino-1-methylquinolinium |
| Molecular Weight | 528.662 g/mol | 178.23 g/mol |
| Half-Life | ~24 hours | ~6 hours |
| Amino Acids | Non-peptide compound | Small molecule |
| Typical Dose | — | — |
| Route | — | — |
| Purity | >99% | >98% |
| Studies Count | 120 | 28 |
| Research Status | Active Research | Active Research |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.