Larazotide vs Histatin-5
Head-to-head comparison of Larazotide (Larazotide acetate (AT-1001)) and Histatin-5 (Human histatin 5) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Larazotide | Histatin-5 |
|---|---|---|
| Category | Gastrointestinal | Dental & Oral |
| Full Name | Larazotide acetate (AT-1001) | Human histatin 5 |
| Molecular Weight | N/A | 3035 Da |
| Half-Life | short; designed for local gut action | minutes in saliva |
| Amino Acids | 8 | 24 |
| Typical Dose | 0.5-4 mg TID (clinical studies) | 1-100 µM in research formulations |
| Route | Oral | Topical/Oral rinse |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 120 |
| Research Status | Clinical | Pre-clinical |
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
Research Overview
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
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