IGF-1 DES vs Cholecystokinin-8
Head-to-head comparison of IGF-1 DES (Des(1-3) Insulin-like Growth Factor 1) and Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | IGF-1 DES | Cholecystokinin-8 |
|---|---|---|
| Category | Growth Hormone | Endocrine Peptides |
| Full Name | Des(1-3) Insulin-like Growth Factor 1 | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) |
| Molecular Weight | 7365 Da | 1143.2 Da |
| Half-Life | ~20-30 minutes | 1-2 min |
| Amino Acids | 67 | DY(SO3H)MGWMDF-NH2 |
| Typical Dose | — | physiologic low-picomolar-nanomolar range|research-dependent |
| Route | — | endogenous secretion|research IV/SC |
| Purity | >98% | ≥98% |
| Studies Count | 65 | 97 |
| Research Status | Active Research | Endogenous |
IGF-1 DES Benefits
- ✓Highly potent localized muscle growth, enhanced protein synthesis, satellite cell proliferation, does not bind to IGFBPs, rapid onset
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
IGF-1 DES Dosing
50-150 mcg per injection site bilaterally post-workout. 4-6 week cycles due to potency. Multiple daily injections in research.
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
IGF-1 DES Side Effects
- ⚠Hypoglycemia (dose-dependent), localized swelling, shorter duration limits systemic exposure compared to IGF-1 LR3.
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Research Overview
IGF-1 DES
Missing first three amino acids (Gly-Pro-Glu) eliminates IGFBP binding, resulting in 100% bioavailable IGF-1R stimulation. Activates PI3K/Akt/mTOR for protein synthesis and satellite cell proliferation.
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
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