HD5 vs HNP-1
Head-to-head comparison of HD5 (Human Alpha-Defensin 5) and HNP-1 (Human Neutrophil Peptide 1 (Alpha-Defensin 1)) — benefits, dosing, side effects, research data, and where to buy.
| Property | HD5 | HNP-1 |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | Human Alpha-Defensin 5 | Human Neutrophil Peptide 1 (Alpha-Defensin 1) |
| Molecular Weight | 3708 Da | 3443 Da |
| Half-Life | Minutes to hours; protease-sensitive | Minutes to hours; protease-sensitive |
| Amino Acids | 32 | 30 |
| Typical Dose | Research use only; no approved human dose | Research use only; no approved human dose |
| Route | Oral-local gut / Research parenteral | Topical / Research parenteral |
| Purity | ≥98% | ≥98% |
| Studies Count | 260 | 610 |
| Research Status | Pre-clinical | Pre-clinical |
HD5 Benefits
- ✓gut mucosal defense
- ✓antimicrobial activity
- ✓microbiome balance support
- ✓barrier integrity support
HNP-1 Benefits
- ✓neutrophil-derived antimicrobial defense
- ✓broad pathogen killing
- ✓immune cell signaling
- ✓mucosal protection
HD5 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
HNP-1 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
HD5 Side Effects
- ⚠protease sensitivity
- ⚠potential epithelial irritation at high concentrations
- ⚠unknown systemic safety
HNP-1 Side Effects
- ⚠membrane toxicity at high concentrations
- ⚠short in vivo stability
- ⚠potential inflammation amplification
Research Overview
HD5
HD5 has been widely studied in intestinal innate immunity, particularly for its role in defending crypts against bacterial invasion. Preclinical literature supports activity against multiple microbes and links altered HD5 biology with gut barrier dysfunction.
HNP-1
HNP-1 has been studied as a key component of neutrophil-mediated host defense against bacteria, fungi, and some enveloped viruses. Literature also reports immunomodulatory effects, including impacts on chemotaxis, cytokine release, and barrier defense.
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