HD5 vs Thymalin
Head-to-head comparison of HD5 (Human Alpha-Defensin 5) and Thymalin (Calf Thymus Peptide Fraction (Thymalin)) — benefits, dosing, side effects, research data, and where to buy.
| Property | HD5 | Thymalin |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | Human Alpha-Defensin 5 | Calf Thymus Peptide Fraction (Thymalin) |
| Molecular Weight | 3708 Da | N/A |
| Half-Life | Minutes to hours; protease-sensitive | N/A |
| Amino Acids | 32 | N/A |
| Typical Dose | Research use only; no approved human dose | 5-20 mg |
| Route | Oral-local gut / Research parenteral | Intramuscular |
| Purity | ≥98% | ≥98% |
| Studies Count | 260 | 120 |
| Research Status | Pre-clinical | Clinical |
HD5 Benefits
- ✓gut mucosal defense
- ✓antimicrobial activity
- ✓microbiome balance support
- ✓barrier integrity support
Thymalin Benefits
- ✓t-cell support
- ✓leukocyte recovery
- ✓immunomodulation
- ✓infection-resilience
HD5 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
Thymalin Dosing
5-10 mg IM daily|3-10 day cycles|repeat cycles after 1-4 weeks if studied
HD5 Side Effects
- ⚠protease sensitivity
- ⚠potential epithelial irritation at high concentrations
- ⚠unknown systemic safety
Thymalin Side Effects
- ⚠injection-site discomfort
- ⚠transient fever
- ⚠rash/allergy
Research Overview
HD5
HD5 has been widely studied in intestinal innate immunity, particularly for its role in defending crypts against bacterial invasion. Preclinical literature supports activity against multiple microbes and links altered HD5 biology with gut barrier dysfunction.
Thymalin
Thymalin appears in Soviet/Russian clinical literature as a thymus peptide complex used to normalize immune parameters after illness, surgery, or radiation exposure. Reports commonly focus on changes in lymphocyte subsets, phagocytic activity, and infection frequency rather than a single isolated peptide mechanism.
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