HD5 vs Thymogen
Head-to-head comparison of HD5 (Human Alpha-Defensin 5) and Thymogen (L-Glutamyl-L-Tryptophan) — benefits, dosing, side effects, research data, and where to buy.
| Property | HD5 | Thymogen |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | Human Alpha-Defensin 5 | L-Glutamyl-L-Tryptophan |
| Molecular Weight | 3708 Da | 345.34 Da |
| Half-Life | Minutes to hours; protease-sensitive | 1-2 h |
| Amino Acids | 32 | 2 |
| Typical Dose | Research use only; no approved human dose | 100-300 mcg |
| Route | Oral-local gut / Research parenteral | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 260 | 60 |
| Research Status | Pre-clinical | Clinical |
HD5 Benefits
- ✓gut mucosal defense
- ✓antimicrobial activity
- ✓microbiome balance support
- ✓barrier integrity support
Thymogen Benefits
- ✓cellular-immune-support
- ✓t-cell-signaling
- ✓recovery-adjunct
- ✓infection-resilience
HD5 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
Thymogen Dosing
100-300 mcg/day|intranasal or IM|5-10 day cycles
HD5 Side Effects
- ⚠protease sensitivity
- ⚠potential epithelial irritation at high concentrations
- ⚠unknown systemic safety
Thymogen Side Effects
- ⚠nasal irritation
- ⚠headache
- ⚠hypersensitivity
Research Overview
HD5
HD5 has been widely studied in intestinal innate immunity, particularly for its role in defending crypts against bacterial invasion. Preclinical literature supports activity against multiple microbes and links altered HD5 biology with gut barrier dysfunction.
Thymogen
Thymogen has been studied as a short thymic peptide-like dipeptide with immunoregulatory activity. The literature focuses on lymphocyte function, cytokine modulation, and use in recurrent respiratory infections or immune suppression states.
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