Histatin-5 vs REGN1033
Head-to-head comparison of Histatin-5 (Human histatin 5) and REGN1033 (Trevogrumab (REGN1033)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Histatin-5 | REGN1033 |
|---|---|---|
| Category | Dental & Oral | Muscle & Performance |
| Full Name | Human histatin 5 | Trevogrumab (REGN1033) |
| Molecular Weight | 3035 Da | ~150 kDa |
| Half-Life | minutes in saliva | ~2-3 weeks |
| Amino Acids | 24 | N/A |
| Typical Dose | 1-100 µM in research formulations | 100-300 mg SC or equivalent trial dosing |
| Route | Topical/Oral rinse | Subcutaneous / Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 60 |
| Research Status | Pre-clinical | Clinical |
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
REGN1033 Benefits
- ✓myostatin blockade
- ✓lean-mass preservation
- ✓muscle hypertrophy support
- ✓catabolic-state countermeasure
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
REGN1033 Dosing
SC or IV clinical-trial dosing|repeat every 2-4 weeks|dose escalation by study
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
REGN1033 Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠fatigue
Research Overview
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
REGN1033
Human and animal studies indicate that myostatin neutralization can increase muscle size, though functional gains are often smaller than mass gains. Trevogrumab is part of the broader literature showing that selective myostatin inhibition can alter body composition in clinically meaningful ways.
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