Histatin-5 vs FS315
Head-to-head comparison of Histatin-5 (Human histatin 5) and FS315 (Follistatin-315 (FS315)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Histatin-5 | FS315 |
|---|---|---|
| Category | Dental & Oral | Muscle & Performance |
| Full Name | Human histatin 5 | Follistatin-315 (FS315) |
| Molecular Weight | 3035 Da | ~40 kDa |
| Half-Life | minutes in saliva | N/A; depends on construct/delivery |
| Amino Acids | 24 | 315 |
| Typical Dose | 1-100 µM in research formulations | Research-only; no standardized human dose |
| Route | Topical/Oral rinse | Intramuscular / research expression systems |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 95 |
| Research Status | Pre-clinical | Pre-clinical |
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
FS315 Benefits
- ✓activin neutralization
- ✓muscle growth signaling
- ✓anti-catabolic support
- ✓tissue repair modulation
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
FS315 Dosing
Research-only recombinant/protein-expression studies|no standardized clinical dose|route varies by platform
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
FS315 Side Effects
- ⚠off-target endocrine effects
- ⚠immune response risk
- ⚠fluid balance changes
Research Overview
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
FS315
Follistatin-315 is a key reference isoform in studies of muscle anabolism and reproductive/endocrine biology. In muscle research, it is relevant because it suppresses activin and can indirectly blunt myostatin pathway output.
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