Histatin-5 vs ACE-031
Head-to-head comparison of Histatin-5 (Human histatin 5) and ACE-031 (ACE-031 (soluble activin receptor type IIB-Fc)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Histatin-5 | ACE-031 |
|---|---|---|
| Category | Dental & Oral | Muscle & Performance |
| Full Name | Human histatin 5 | ACE-031 (soluble activin receptor type IIB-Fc) |
| Molecular Weight | 3035 Da | ~95 kDa |
| Half-Life | minutes in saliva | Days to weeks |
| Amino Acids | 24 | N/A |
| Typical Dose | 1-100 µM in research formulations | 0.1-3 mg/kg in early studies |
| Route | Topical/Oral rinse | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 75 |
| Research Status | Pre-clinical | Clinical |
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
ACE-031 Benefits
- ✓myostatin/activin neutralization
- ✓lean mass gain
- ✓muscle function support
- ✓anti-catabolic effect
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
ACE-031 Dosing
Clinical studies used single or repeated SC doses|dose escalation in mg/kg|monitoring for edema/bleeding
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
ACE-031 Side Effects
- ⚠telangiectasia/vascular effects
- ⚠epistaxis
- ⚠headache/edema
Research Overview
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
ACE-031
ACE-031 produced increases in lean mass in early studies, but development was curtailed after safety concerns and variable efficacy. Its literature remains important because it validated activin receptor blockade as a muscle-building strategy.
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