Hexapeptide-9 vs Eyeseryl
Head-to-head comparison of Hexapeptide-9 (Hexapeptide-9) and Eyeseryl (Acetyl Tetrapeptide-5) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Hexapeptide-9 | Eyeseryl |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Hexapeptide-9 | Acetyl Tetrapeptide-5 |
| Molecular Weight | 681.7 Da | 492.5 Da |
| Half-Life | N/A | N/A |
| Amino Acids | 6 | 4 |
| Typical Dose | 0.01-1% in cosmetic formulations | 0.5-2% in eye-area cosmetic products |
| Route | Topical | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 12 | 18 |
| Research Status | Pre-clinical | Clinical |
Hexapeptide-9 Benefits
- ✓skin-repair support
- ✓collagen-matrix support
- ✓fine-line appearance reduction
- ✓topical rejuvenation
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Hexapeptide-9 Dosing
Topical serum/cream 0.01-1%|Apply once or twice daily|Use consistently for visible cosmetic effects
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Hexapeptide-9 Side Effects
- ⚠mild redness
- ⚠temporary stinging
- ⚠sensitivity in reactive skin
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Research Overview
Hexapeptide-9
Hexapeptide-9 appears in scientific and cosmetic literature related to wound repair, cell migration, and extracellular matrix support. The evidence base is smaller than for more established peptides, but it is a real research-backed cosmetic ingredient.
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
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