Eyeseryl vs Tetracosactide
Head-to-head comparison of Eyeseryl (Acetyl Tetrapeptide-5) and Tetracosactide (Tetracosactide (ACTH 1-24, Cosyntropin)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Eyeseryl | Tetracosactide |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Acetyl Tetrapeptide-5 | Tetracosactide (ACTH 1-24, Cosyntropin) |
| Molecular Weight | 492.5 Da | 2933 Da |
| Half-Life | N/A | ~15 minutes |
| Amino Acids | 4 | 24 |
| Typical Dose | 0.5-2% in eye-area cosmetic products | 10–1000 nM |
| Route | Topical | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 18 | 220 |
| Research Status | Clinical | Clinical/Pre-clinical |
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Tetracosactide Benefits
- ✓Melanocortin receptor activation
- ✓Supports melanocyte research assays
- ✓Useful for adrenal-axis studies
- ✓Can inform pigmentation models
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Tetracosactide Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Tetracosactide Side Effects
- ⚠Endocrine activity in vivo
- ⚠Transient membrane stress
- ⚠Peptide instability
Research Overview
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
Tetracosactide
Tetracosactide is the synthetic ACTH(1-24) fragment and is commonly used to probe melanocortin receptor signaling. Its melanogenic relevance comes from the same N-terminal motif that drives ACTH-related pigmentation effects.
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