Tetracosactide vs Gamma-MSH
Head-to-head comparison of Tetracosactide (Tetracosactide (ACTH 1-24, Cosyntropin)) and Gamma-MSH (Gamma-Melanocyte-Stimulating Hormone) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tetracosactide | Gamma-MSH |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Tetracosactide (ACTH 1-24, Cosyntropin) | Gamma-Melanocyte-Stimulating Hormone |
| Molecular Weight | 2933 Da | N/A |
| Half-Life | ~15 minutes | Minutes |
| Amino Acids | 24 | 12 |
| Typical Dose | 10–1000 nM | 10–500 nM |
| Route | In vitro / ex vivo | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 220 | 45 |
| Research Status | Clinical/Pre-clinical | Pre-clinical |
Tetracosactide Benefits
- ✓Melanocortin receptor activation
- ✓Supports melanocyte research assays
- ✓Useful for adrenal-axis studies
- ✓Can inform pigmentation models
Gamma-MSH Benefits
- ✓Melanocortin signaling
- ✓Pigment-pathway research
- ✓May modulate melanocyte activity
- ✓Useful for UV-response studies
Tetracosactide Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Gamma-MSH Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Tetracosactide Side Effects
- ⚠Endocrine activity in vivo
- ⚠Transient membrane stress
- ⚠Peptide instability
Gamma-MSH Side Effects
- ⚠Short peptide half-life
- ⚠Receptor promiscuity
- ⚠Limited metabolic stability
Research Overview
Tetracosactide
Tetracosactide is the synthetic ACTH(1-24) fragment and is commonly used to probe melanocortin receptor signaling. Its melanogenic relevance comes from the same N-terminal motif that drives ACTH-related pigmentation effects.
Gamma-MSH
Gamma-MSH has been investigated as part of the broader melanocortin network that regulates pigmentation. Evidence suggests it can contribute to melanocyte signaling, though its cosmetic use remains experimental.
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