Tetracosactide vs Eyeseryl
Head-to-head comparison of Tetracosactide (Tetracosactide (ACTH 1-24, Cosyntropin)) and Eyeseryl (Acetyl Tetrapeptide-5) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tetracosactide | Eyeseryl |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Tetracosactide (ACTH 1-24, Cosyntropin) | Acetyl Tetrapeptide-5 |
| Molecular Weight | 2933 Da | 492.5 Da |
| Half-Life | ~15 minutes | N/A |
| Amino Acids | 24 | 4 |
| Typical Dose | 10–1000 nM | 0.5-2% in eye-area cosmetic products |
| Route | In vitro / ex vivo | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 220 | 18 |
| Research Status | Clinical/Pre-clinical | Clinical |
Tetracosactide Benefits
- ✓Melanocortin receptor activation
- ✓Supports melanocyte research assays
- ✓Useful for adrenal-axis studies
- ✓Can inform pigmentation models
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Tetracosactide Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Tetracosactide Side Effects
- ⚠Endocrine activity in vivo
- ⚠Transient membrane stress
- ⚠Peptide instability
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Research Overview
Tetracosactide
Tetracosactide is the synthetic ACTH(1-24) fragment and is commonly used to probe melanocortin receptor signaling. Its melanogenic relevance comes from the same N-terminal motif that drives ACTH-related pigmentation effects.
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
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