Eyeseryl vs Gamma-MSH
Head-to-head comparison of Eyeseryl (Acetyl Tetrapeptide-5) and Gamma-MSH (Gamma-Melanocyte-Stimulating Hormone) — benefits, dosing, side effects, research data, and where to buy.
| Property | Eyeseryl | Gamma-MSH |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Acetyl Tetrapeptide-5 | Gamma-Melanocyte-Stimulating Hormone |
| Molecular Weight | 492.5 Da | N/A |
| Half-Life | N/A | Minutes |
| Amino Acids | 4 | 12 |
| Typical Dose | 0.5-2% in eye-area cosmetic products | 10–500 nM |
| Route | Topical | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 18 | 45 |
| Research Status | Clinical | Pre-clinical |
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Gamma-MSH Benefits
- ✓Melanocortin signaling
- ✓Pigment-pathway research
- ✓May modulate melanocyte activity
- ✓Useful for UV-response studies
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Gamma-MSH Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Gamma-MSH Side Effects
- ⚠Short peptide half-life
- ⚠Receptor promiscuity
- ⚠Limited metabolic stability
Research Overview
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
Gamma-MSH
Gamma-MSH has been investigated as part of the broader melanocortin network that regulates pigmentation. Evidence suggests it can contribute to melanocyte signaling, though its cosmetic use remains experimental.
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