Eyeseryl vs Beta-MSH
Head-to-head comparison of Eyeseryl (Acetyl Tetrapeptide-5) and Beta-MSH (Beta-Melanocyte-Stimulating Hormone) — benefits, dosing, side effects, research data, and where to buy.
| Property | Eyeseryl | Beta-MSH |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Acetyl Tetrapeptide-5 | Beta-Melanocyte-Stimulating Hormone |
| Molecular Weight | 492.5 Da | N/A |
| Half-Life | N/A | Minutes |
| Amino Acids | 4 | 18 |
| Typical Dose | 0.5-2% in eye-area cosmetic products | 10–500 nM |
| Route | Topical | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 18 | 80 |
| Research Status | Clinical | Pre-clinical |
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Beta-MSH Benefits
- ✓Promotes melanogenesis
- ✓Supports melanocyte dendricity
- ✓Useful in pigmentation pathway mapping
- ✓May increase eumelanin bias
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Beta-MSH Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Beta-MSH Side Effects
- ⚠Short peptide half-life
- ⚠Receptor cross-talk
- ⚠Limited plasma stability
Research Overview
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
Beta-MSH
Beta-MSH is one of the endogenous melanocortin peptides studied for its ability to influence melanin synthesis. Most evidence is mechanistic, focusing on receptor signaling and melanocyte biology rather than cosmetic use.
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