Eyeseryl vs Endothelin-1
Head-to-head comparison of Eyeseryl (Acetyl Tetrapeptide-5) and Endothelin-1 (Endothelin-1) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Eyeseryl | Endothelin-1 |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Acetyl Tetrapeptide-5 | Endothelin-1 |
| Molecular Weight | 492.5 Da | 2493 Da |
| Half-Life | N/A | ~2–10 minutes |
| Amino Acids | 4 | 21 |
| Typical Dose | 0.5-2% in eye-area cosmetic products | 1–100 nM |
| Route | Topical | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 18 | 350 |
| Research Status | Clinical | Pre-clinical |
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Endothelin-1 Benefits
- ✓Stimulates melanocyte activity
- ✓Supports melanosome transfer studies
- ✓Useful in UV-induced pigmentation research
- ✓Links vascular and pigment signaling
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Endothelin-1 Dosing
1 nM exposure|10 nM exposure|100 nM exposure
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Endothelin-1 Side Effects
- ⚠Vasoconstriction
- ⚠Cell-stress signaling at high concentrations
- ⚠Inflammatory cross-talk
Research Overview
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
Endothelin-1
Endothelin-1 is one of the best-studied non-melanocortin regulators of pigmentation in human skin. It is strongly associated with UV-induced tanning responses and pigment disorder biology.
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