Endothelin-1 vs Tetracosactide
Head-to-head comparison of Endothelin-1 (Endothelin-1) and Tetracosactide (Tetracosactide (ACTH 1-24, Cosyntropin)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endothelin-1 | Tetracosactide |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Endothelin-1 | Tetracosactide (ACTH 1-24, Cosyntropin) |
| Molecular Weight | 2493 Da | 2933 Da |
| Half-Life | ~2–10 minutes | ~15 minutes |
| Amino Acids | 21 | 24 |
| Typical Dose | 1–100 nM | 10–1000 nM |
| Route | In vitro / ex vivo | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 350 | 220 |
| Research Status | Pre-clinical | Clinical/Pre-clinical |
Endothelin-1 Benefits
- ✓Stimulates melanocyte activity
- ✓Supports melanosome transfer studies
- ✓Useful in UV-induced pigmentation research
- ✓Links vascular and pigment signaling
Tetracosactide Benefits
- ✓Melanocortin receptor activation
- ✓Supports melanocyte research assays
- ✓Useful for adrenal-axis studies
- ✓Can inform pigmentation models
Endothelin-1 Dosing
1 nM exposure|10 nM exposure|100 nM exposure
Tetracosactide Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Endothelin-1 Side Effects
- ⚠Vasoconstriction
- ⚠Cell-stress signaling at high concentrations
- ⚠Inflammatory cross-talk
Tetracosactide Side Effects
- ⚠Endocrine activity in vivo
- ⚠Transient membrane stress
- ⚠Peptide instability
Research Overview
Endothelin-1
Endothelin-1 is one of the best-studied non-melanocortin regulators of pigmentation in human skin. It is strongly associated with UV-induced tanning responses and pigment disorder biology.
Tetracosactide
Tetracosactide is the synthetic ACTH(1-24) fragment and is commonly used to probe melanocortin receptor signaling. Its melanogenic relevance comes from the same N-terminal motif that drives ACTH-related pigmentation effects.
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