Endothelin-1 vs Eyeseryl
Head-to-head comparison of Endothelin-1 (Endothelin-1) and Eyeseryl (Acetyl Tetrapeptide-5) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endothelin-1 | Eyeseryl |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Endothelin-1 | Acetyl Tetrapeptide-5 |
| Molecular Weight | 2493 Da | 492.5 Da |
| Half-Life | ~2–10 minutes | N/A |
| Amino Acids | 21 | 4 |
| Typical Dose | 1–100 nM | 0.5-2% in eye-area cosmetic products |
| Route | In vitro / ex vivo | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 350 | 18 |
| Research Status | Pre-clinical | Clinical |
Endothelin-1 Benefits
- ✓Stimulates melanocyte activity
- ✓Supports melanosome transfer studies
- ✓Useful in UV-induced pigmentation research
- ✓Links vascular and pigment signaling
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Endothelin-1 Dosing
1 nM exposure|10 nM exposure|100 nM exposure
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Endothelin-1 Side Effects
- ⚠Vasoconstriction
- ⚠Cell-stress signaling at high concentrations
- ⚠Inflammatory cross-talk
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Research Overview
Endothelin-1
Endothelin-1 is one of the best-studied non-melanocortin regulators of pigmentation in human skin. It is strongly associated with UV-induced tanning responses and pigment disorder biology.
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
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