Endothelin-1 vs Gamma-MSH
Head-to-head comparison of Endothelin-1 (Endothelin-1) and Gamma-MSH (Gamma-Melanocyte-Stimulating Hormone) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endothelin-1 | Gamma-MSH |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Endothelin-1 | Gamma-Melanocyte-Stimulating Hormone |
| Molecular Weight | 2493 Da | N/A |
| Half-Life | ~2–10 minutes | Minutes |
| Amino Acids | 21 | 12 |
| Typical Dose | 1–100 nM | 10–500 nM |
| Route | In vitro / ex vivo | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 350 | 45 |
| Research Status | Pre-clinical | Pre-clinical |
Endothelin-1 Benefits
- ✓Stimulates melanocyte activity
- ✓Supports melanosome transfer studies
- ✓Useful in UV-induced pigmentation research
- ✓Links vascular and pigment signaling
Gamma-MSH Benefits
- ✓Melanocortin signaling
- ✓Pigment-pathway research
- ✓May modulate melanocyte activity
- ✓Useful for UV-response studies
Endothelin-1 Dosing
1 nM exposure|10 nM exposure|100 nM exposure
Gamma-MSH Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Endothelin-1 Side Effects
- ⚠Vasoconstriction
- ⚠Cell-stress signaling at high concentrations
- ⚠Inflammatory cross-talk
Gamma-MSH Side Effects
- ⚠Short peptide half-life
- ⚠Receptor promiscuity
- ⚠Limited metabolic stability
Research Overview
Endothelin-1
Endothelin-1 is one of the best-studied non-melanocortin regulators of pigmentation in human skin. It is strongly associated with UV-induced tanning responses and pigment disorder biology.
Gamma-MSH
Gamma-MSH has been investigated as part of the broader melanocortin network that regulates pigmentation. Evidence suggests it can contribute to melanocyte signaling, though its cosmetic use remains experimental.
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