Endothelin-1 vs ACTH
Head-to-head comparison of Endothelin-1 (Endothelin-1) and ACTH (Adrenocorticotropic Hormone (Corticotropin)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endothelin-1 | ACTH |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Endothelin-1 | Adrenocorticotropic Hormone (Corticotropin) |
| Molecular Weight | 2493 Da | 4541 Da |
| Half-Life | ~2–10 minutes | ~10 minutes |
| Amino Acids | 21 | 39 |
| Typical Dose | 1–100 nM | 10–1000 nM |
| Route | In vitro / ex vivo | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 350 | 500 |
| Research Status | Pre-clinical | Clinical/Pre-clinical |
Endothelin-1 Benefits
- ✓Stimulates melanocyte activity
- ✓Supports melanosome transfer studies
- ✓Useful in UV-induced pigmentation research
- ✓Links vascular and pigment signaling
ACTH Benefits
- ✓Stimulates melanogenesis
- ✓Supports eumelanin production
- ✓Useful for pigmentation-pathway research
- ✓May model UV-response signaling
Endothelin-1 Dosing
1 nM exposure|10 nM exposure|100 nM exposure
ACTH Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Endothelin-1 Side Effects
- ⚠Vasoconstriction
- ⚠Cell-stress signaling at high concentrations
- ⚠Inflammatory cross-talk
ACTH Side Effects
- ⚠Receptor desensitization
- ⚠Off-target melanocortin signaling
- ⚠Rapid proteolysis
Research Overview
Endothelin-1
Endothelin-1 is one of the best-studied non-melanocortin regulators of pigmentation in human skin. It is strongly associated with UV-induced tanning responses and pigment disorder biology.
ACTH
ACTH activates melanocortin receptors on melanocytes and can increase pigment synthesis. It is widely used as a reference peptide in studies of tanning, adrenal biology, and hyperpigmentation.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.