ACTH vs Tetracosactide
Head-to-head comparison of ACTH (Adrenocorticotropic Hormone (Corticotropin)) and Tetracosactide (Tetracosactide (ACTH 1-24, Cosyntropin)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | ACTH | Tetracosactide |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Adrenocorticotropic Hormone (Corticotropin) | Tetracosactide (ACTH 1-24, Cosyntropin) |
| Molecular Weight | 4541 Da | 2933 Da |
| Half-Life | ~10 minutes | ~15 minutes |
| Amino Acids | 39 | 24 |
| Typical Dose | 10–1000 nM | 10–1000 nM |
| Route | In vitro / ex vivo | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 500 | 220 |
| Research Status | Clinical/Pre-clinical | Clinical/Pre-clinical |
ACTH Benefits
- ✓Stimulates melanogenesis
- ✓Supports eumelanin production
- ✓Useful for pigmentation-pathway research
- ✓May model UV-response signaling
Tetracosactide Benefits
- ✓Melanocortin receptor activation
- ✓Supports melanocyte research assays
- ✓Useful for adrenal-axis studies
- ✓Can inform pigmentation models
ACTH Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Tetracosactide Dosing
10 nM exposure|100 nM exposure|1 uM exposure
ACTH Side Effects
- ⚠Receptor desensitization
- ⚠Off-target melanocortin signaling
- ⚠Rapid proteolysis
Tetracosactide Side Effects
- ⚠Endocrine activity in vivo
- ⚠Transient membrane stress
- ⚠Peptide instability
Research Overview
ACTH
ACTH activates melanocortin receptors on melanocytes and can increase pigment synthesis. It is widely used as a reference peptide in studies of tanning, adrenal biology, and hyperpigmentation.
Tetracosactide
Tetracosactide is the synthetic ACTH(1-24) fragment and is commonly used to probe melanocortin receptor signaling. Its melanogenic relevance comes from the same N-terminal motif that drives ACTH-related pigmentation effects.
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