ACTH vs Eyeseryl
Head-to-head comparison of ACTH (Adrenocorticotropic Hormone (Corticotropin)) and Eyeseryl (Acetyl Tetrapeptide-5) — benefits, dosing, side effects, research data, and where to buy.
| Property | ACTH | Eyeseryl |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Adrenocorticotropic Hormone (Corticotropin) | Acetyl Tetrapeptide-5 |
| Molecular Weight | 4541 Da | 492.5 Da |
| Half-Life | ~10 minutes | N/A |
| Amino Acids | 39 | 4 |
| Typical Dose | 10–1000 nM | 0.5-2% in eye-area cosmetic products |
| Route | In vitro / ex vivo | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 500 | 18 |
| Research Status | Clinical/Pre-clinical | Clinical |
ACTH Benefits
- ✓Stimulates melanogenesis
- ✓Supports eumelanin production
- ✓Useful for pigmentation-pathway research
- ✓May model UV-response signaling
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
ACTH Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
ACTH Side Effects
- ⚠Receptor desensitization
- ⚠Off-target melanocortin signaling
- ⚠Rapid proteolysis
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Research Overview
ACTH
ACTH activates melanocortin receptors on melanocytes and can increase pigment synthesis. It is widely used as a reference peptide in studies of tanning, adrenal biology, and hyperpigmentation.
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
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