Hexapeptide-9 vs Leuphasyl
Head-to-head comparison of Hexapeptide-9 (Hexapeptide-9) and Leuphasyl (Pentapeptide-18) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Hexapeptide-9 | Leuphasyl |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Hexapeptide-9 | Pentapeptide-18 |
| Molecular Weight | 681.7 Da | 569.6 Da |
| Half-Life | N/A | N/A |
| Amino Acids | 6 | 5 |
| Typical Dose | 0.01-1% in cosmetic formulations | 0.01-2% in cosmetic formulations |
| Route | Topical | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 12 | 22 |
| Research Status | Pre-clinical | Clinical |
Hexapeptide-9 Benefits
- ✓skin-repair support
- ✓collagen-matrix support
- ✓fine-line appearance reduction
- ✓topical rejuvenation
Leuphasyl Benefits
- ✓wrinkle-appearance reduction
- ✓expression-line softening
- ✓topical anti-aging support
- ✓cosmetic skin-smoothing
Hexapeptide-9 Dosing
Topical serum/cream 0.01-1%|Apply once or twice daily|Use consistently for visible cosmetic effects
Leuphasyl Dosing
Topical serum/cream 0.01-2%|Apply once or twice daily|Combine with moisturizer or peptide serum
Hexapeptide-9 Side Effects
- ⚠mild redness
- ⚠temporary stinging
- ⚠sensitivity in reactive skin
Leuphasyl Side Effects
- ⚠temporary redness
- ⚠mild irritation
- ⚠sensitivity in compromised skin
Research Overview
Hexapeptide-9
Hexapeptide-9 appears in scientific and cosmetic literature related to wound repair, cell migration, and extracellular matrix support. The evidence base is smaller than for more established peptides, but it is a real research-backed cosmetic ingredient.
Leuphasyl
Pentapeptide-18 has published cosmetic and formulation literature supporting its use in anti-aging skincare. Evidence is strongest for topical cosmetic smoothing rather than deep structural remodeling.
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