Leuphasyl vs Tetracosactide
Head-to-head comparison of Leuphasyl (Pentapeptide-18) and Tetracosactide (Tetracosactide (ACTH 1-24, Cosyntropin)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Leuphasyl | Tetracosactide |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Pentapeptide-18 | Tetracosactide (ACTH 1-24, Cosyntropin) |
| Molecular Weight | 569.6 Da | 2933 Da |
| Half-Life | N/A | ~15 minutes |
| Amino Acids | 5 | 24 |
| Typical Dose | 0.01-2% in cosmetic formulations | 10–1000 nM |
| Route | Topical | In vitro / ex vivo |
| Purity | ≥98% | ≥98% |
| Studies Count | 22 | 220 |
| Research Status | Clinical | Clinical/Pre-clinical |
Leuphasyl Benefits
- ✓wrinkle-appearance reduction
- ✓expression-line softening
- ✓topical anti-aging support
- ✓cosmetic skin-smoothing
Tetracosactide Benefits
- ✓Melanocortin receptor activation
- ✓Supports melanocyte research assays
- ✓Useful for adrenal-axis studies
- ✓Can inform pigmentation models
Leuphasyl Dosing
Topical serum/cream 0.01-2%|Apply once or twice daily|Combine with moisturizer or peptide serum
Tetracosactide Dosing
10 nM exposure|100 nM exposure|1 uM exposure
Leuphasyl Side Effects
- ⚠temporary redness
- ⚠mild irritation
- ⚠sensitivity in compromised skin
Tetracosactide Side Effects
- ⚠Endocrine activity in vivo
- ⚠Transient membrane stress
- ⚠Peptide instability
Research Overview
Leuphasyl
Pentapeptide-18 has published cosmetic and formulation literature supporting its use in anti-aging skincare. Evidence is strongest for topical cosmetic smoothing rather than deep structural remodeling.
Tetracosactide
Tetracosactide is the synthetic ACTH(1-24) fragment and is commonly used to probe melanocortin receptor signaling. Its melanogenic relevance comes from the same N-terminal motif that drives ACTH-related pigmentation effects.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.