Leuphasyl vs Eyeseryl
Head-to-head comparison of Leuphasyl (Pentapeptide-18) and Eyeseryl (Acetyl Tetrapeptide-5) — benefits, dosing, side effects, research data, and where to buy.
| Property | Leuphasyl | Eyeseryl |
|---|---|---|
| Category | Skin & Cosmetic | Skin & Cosmetic |
| Full Name | Pentapeptide-18 | Acetyl Tetrapeptide-5 |
| Molecular Weight | 569.6 Da | 492.5 Da |
| Half-Life | N/A | N/A |
| Amino Acids | 5 | 4 |
| Typical Dose | 0.01-2% in cosmetic formulations | 0.5-2% in eye-area cosmetic products |
| Route | Topical | Topical |
| Purity | ≥98% | ≥98% |
| Studies Count | 22 | 18 |
| Research Status | Clinical | Clinical |
Leuphasyl Benefits
- ✓wrinkle-appearance reduction
- ✓expression-line softening
- ✓topical anti-aging support
- ✓cosmetic skin-smoothing
Eyeseryl Benefits
- ✓under-eye puffiness reduction
- ✓cosmetic firming support
- ✓appearance of dark circles
- ✓eye-area smoothing
Leuphasyl Dosing
Topical serum/cream 0.01-2%|Apply once or twice daily|Combine with moisturizer or peptide serum
Eyeseryl Dosing
Topical eye cream 0.5-2%|Apply 1-2x daily under eyes|Use gently on intact skin only
Leuphasyl Side Effects
- ⚠temporary redness
- ⚠mild irritation
- ⚠sensitivity in compromised skin
Eyeseryl Side Effects
- ⚠eye-area irritation
- ⚠dryness
- ⚠rare contact allergy
Research Overview
Leuphasyl
Pentapeptide-18 has published cosmetic and formulation literature supporting its use in anti-aging skincare. Evidence is strongest for topical cosmetic smoothing rather than deep structural remodeling.
Eyeseryl
Acetyl tetrapeptide-5 has topical cosmetic literature and formulation studies focused on edema reduction and eye-contour improvement. It is mainly used for appearance benefits rather than as a systemic therapeutic peptide.
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