GLP-1 vs P11-4
Head-to-head comparison of GLP-1 (Glucagon-like peptide-1 (7-36 amide)) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
| Property | GLP-1 | P11-4 |
|---|---|---|
| Category | Diabetes & Metabolic | Dental & Oral |
| Full Name | Glucagon-like peptide-1 (7-36 amide) | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | 3297 Da | 1466 Da |
| Half-Life | 1-2 minutes | local activity for hours; peptide degraded over time |
| Amino Acids | 30 | 11 |
| Typical Dose | Research-only: 0.1-1.0 pmol/kg/min | 0.5-5 mg per lesion |
| Route | Intravenous/Subcutaneous | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 40 |
| Research Status | Pre-clinical | Clinical |
GLP-1 Benefits
- ✓beta-cell protection
- ✓improved insulin secretion
- ✓slower gastric emptying
- ✓lower postprandial glucose
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
GLP-1 Dosing
0.1-1.0 pmol/kg/min IV infusion in research|0.5-10 nM in vitro|continuous delivery in animal studies
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
GLP-1 Side Effects
- ⚠nausea at pharmacologic exposure
- ⚠tachyphylaxis with continuous exposure
- ⚠headache
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
GLP-1
Native GLP-1 has a very short half-life because of rapid DPP-4 cleavage, so it is mainly used as a mechanistic research peptide. Across animal and cellular studies it reduces beta-cell apoptosis, improves insulin gene expression, and enhances islet resilience.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.