GLP-1 vs Insulin Lispro
Head-to-head comparison of GLP-1 (Glucagon-like peptide-1 (7-36 amide)) and Insulin Lispro (Insulin lispro (B28-Lys, B29-Pro human insulin analog)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | GLP-1 | Insulin Lispro |
|---|---|---|
| Category | Diabetes & Metabolic | Diabetes & Metabolic |
| Full Name | Glucagon-like peptide-1 (7-36 amide) | Insulin lispro (B28-Lys, B29-Pro human insulin analog) |
| Molecular Weight | 3297 Da | 5808.0 Da |
| Half-Life | 1-2 minutes | About 1 hour |
| Amino Acids | 30 | 51 |
| Typical Dose | Research-only: 0.1-1.0 pmol/kg/min | 0.05-0.2 U/kg per meal |
| Route | Intravenous/Subcutaneous | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 12000 |
| Research Status | Pre-clinical | Approved |
GLP-1 Benefits
- ✓beta-cell protection
- ✓improved insulin secretion
- ✓slower gastric emptying
- ✓lower postprandial glucose
Insulin Lispro Benefits
- ✓Rapid postprandial glucose control
- ✓Flexible premeal timing
- ✓Predictable onset of action
- ✓Useful in basal-bolus regimens
GLP-1 Dosing
0.1-1.0 pmol/kg/min IV infusion in research|0.5-10 nM in vitro|continuous delivery in animal studies
Insulin Lispro Dosing
Inject SC 0-15 minutes before meals|Adjust dose to carbohydrate intake and premeal glucose|Often paired with a basal insulin
GLP-1 Side Effects
- ⚠nausea at pharmacologic exposure
- ⚠tachyphylaxis with continuous exposure
- ⚠headache
Insulin Lispro Side Effects
- ⚠Hypoglycemia
- ⚠Weight gain
- ⚠Injection-site reactions
Research Overview
GLP-1
Native GLP-1 has a very short half-life because of rapid DPP-4 cleavage, so it is mainly used as a mechanistic research peptide. Across animal and cellular studies it reduces beta-cell apoptosis, improves insulin gene expression, and enhances islet resilience.
Insulin Lispro
Clinical studies show faster onset and shorter duration than regular insulin, improving post-meal glucose control. It is a standard comparator in diabetes pharmacology and closed-loop insulin-delivery research.
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