Exendin-4 vs P11-4
Head-to-head comparison of Exendin-4 (Exendin-4 (synthetic exenatide)) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Exendin-4 | P11-4 |
|---|---|---|
| Category | Diabetes & Metabolic | Dental & Oral |
| Full Name | Exendin-4 (synthetic exenatide) | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | 4186 Da | 1466 Da |
| Half-Life | 2.4 hours | local activity for hours; peptide degraded over time |
| Amino Acids | 39 | 11 |
| Typical Dose | 5-10 mcg twice daily | 0.5-5 mg per lesion |
| Route | Subcutaneous | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 1800 | 40 |
| Research Status | Clinical | Clinical |
Exendin-4 Benefits
- ✓beta-cell survival
- ✓glucose-stimulated insulin secretion
- ✓reduced glucolipotoxicity
- ✓lowered HbA1c in clinical use
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Exendin-4 Dosing
5 mcg SC twice daily for 4 weeks|increase to 10 mcg SC twice daily if tolerated|research: 0.1-1 µM in vitro or 1-10 µg/kg in animals
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Exendin-4 Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠injection-site reactions
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
Exendin-4
Exendin-4 helped establish GLP-1 receptor biology in diabetes and remains a classic beta-cell protective peptide. Preclinical studies show reduced beta-cell apoptosis, improved insulin content, and better islet function under metabolic stress.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
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