Endomorphin-1 vs P11-4
Head-to-head comparison of Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endomorphin-1 | P11-4 |
|---|---|---|
| Category | Pain Management | Dental & Oral |
| Full Name | Tyr-Pro-Trp-Phe-NH2 | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | 610.71 Da | 1466 Da |
| Half-Life | Minutes in plasma | local activity for hours; peptide degraded over time |
| Amino Acids | 4 | 11 |
| Typical Dose | 0.1-10 ug per animal | 0.5-5 mg per lesion |
| Route | Intrathecal / subcutaneous | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 600 | 40 |
| Research Status | Pre-clinical | Clinical |
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
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