Elamipretide vs REGN1033
Head-to-head comparison of Elamipretide (Elamipretide (MTP-131, SS-31)) and REGN1033 (Trevogrumab (REGN1033)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Elamipretide | REGN1033 |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Elamipretide (MTP-131, SS-31) | Trevogrumab (REGN1033) |
| Molecular Weight | 639.8 Da | ~150 kDa |
| Half-Life | 1-4 hours | ~2-3 weeks |
| Amino Acids | 4 | N/A |
| Typical Dose | 0.01-0.25 mg/kg/day | 100-300 mg SC or equivalent trial dosing |
| Route | Subcutaneous/Intravenous | Subcutaneous / Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 60 |
| Research Status | Clinical | Clinical |
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
REGN1033 Benefits
- ✓myostatin blockade
- ✓lean-mass preservation
- ✓muscle hypertrophy support
- ✓catabolic-state countermeasure
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
REGN1033 Dosing
SC or IV clinical-trial dosing|repeat every 2-4 weeks|dose escalation by study
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
REGN1033 Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠fatigue
Research Overview
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
REGN1033
Human and animal studies indicate that myostatin neutralization can increase muscle size, though functional gains are often smaller than mass gains. Trevogrumab is part of the broader literature showing that selective myostatin inhibition can alter body composition in clinically meaningful ways.
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