Elamipretide vs FS315
Head-to-head comparison of Elamipretide (Elamipretide (MTP-131, SS-31)) and FS315 (Follistatin-315 (FS315)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Elamipretide | FS315 |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Elamipretide (MTP-131, SS-31) | Follistatin-315 (FS315) |
| Molecular Weight | 639.8 Da | ~40 kDa |
| Half-Life | 1-4 hours | N/A; depends on construct/delivery |
| Amino Acids | 4 | 315 |
| Typical Dose | 0.01-0.25 mg/kg/day | Research-only; no standardized human dose |
| Route | Subcutaneous/Intravenous | Intramuscular / research expression systems |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 95 |
| Research Status | Clinical | Pre-clinical |
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
FS315 Benefits
- ✓activin neutralization
- ✓muscle growth signaling
- ✓anti-catabolic support
- ✓tissue repair modulation
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
FS315 Dosing
Research-only recombinant/protein-expression studies|no standardized clinical dose|route varies by platform
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
FS315 Side Effects
- ⚠off-target endocrine effects
- ⚠immune response risk
- ⚠fluid balance changes
Research Overview
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
FS315
Follistatin-315 is a key reference isoform in studies of muscle anabolism and reproductive/endocrine biology. In muscle research, it is relevant because it suppresses activin and can indirectly blunt myostatin pathway output.
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