Elamipretide vs ACE-031
Head-to-head comparison of Elamipretide (Elamipretide (MTP-131, SS-31)) and ACE-031 (ACE-031 (soluble activin receptor type IIB-Fc)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Elamipretide | ACE-031 |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Elamipretide (MTP-131, SS-31) | ACE-031 (soluble activin receptor type IIB-Fc) |
| Molecular Weight | 639.8 Da | ~95 kDa |
| Half-Life | 1-4 hours | Days to weeks |
| Amino Acids | 4 | N/A |
| Typical Dose | 0.01-0.25 mg/kg/day | 0.1-3 mg/kg in early studies |
| Route | Subcutaneous/Intravenous | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 75 |
| Research Status | Clinical | Clinical |
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
ACE-031 Benefits
- ✓myostatin/activin neutralization
- ✓lean mass gain
- ✓muscle function support
- ✓anti-catabolic effect
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
ACE-031 Dosing
Clinical studies used single or repeated SC doses|dose escalation in mg/kg|monitoring for edema/bleeding
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
ACE-031 Side Effects
- ⚠telangiectasia/vascular effects
- ⚠epistaxis
- ⚠headache/edema
Research Overview
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
ACE-031
ACE-031 produced increases in lean mass in early studies, but development was curtailed after safety concerns and variable efficacy. Its literature remains important because it validated activin receptor blockade as a muscle-building strategy.
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