DADLE vs Insulin Aspart
Head-to-head comparison of DADLE ([D-Ala2, D-Leu5]-enkephalin) and Insulin Aspart (Insulin aspart (B28-Asp human insulin analog)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | DADLE | Insulin Aspart |
|---|---|---|
| Category | Pain Management | Diabetes & Metabolic |
| Full Name | [D-Ala2, D-Leu5]-enkephalin | Insulin aspart (B28-Asp human insulin analog) |
| Molecular Weight | 569.67 Da | 5825.8 Da |
| Half-Life | 5-20 minutes in plasma | About 1-3 hours |
| Amino Acids | 5 | 51 |
| Typical Dose | 0.01-2 ug per animal | 0.05-0.2 U/kg per meal |
| Route | Intrathecal / intracerebroventricular | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 450 | 11000 |
| Research Status | Pre-clinical | Approved |
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
Insulin Aspart Benefits
- ✓Fast post-meal glucose lowering
- ✓Predictable onset
- ✓Flexible mealtime administration
- ✓Compatible with pump therapy
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
Insulin Aspart Dosing
Inject SC immediately before meals|Titrate using glucose monitoring and carbohydrate intake|Can be used in insulin pumps or basal-bolus regimens
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Insulin Aspart Side Effects
- ⚠Hypoglycemia
- ⚠Injection-site reactions
- ⚠Weight gain
Research Overview
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
Insulin Aspart
Research consistently shows faster onset and earlier peak action than regular human insulin. It is commonly studied for meal-time glycemic control and pump-based insulin delivery.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.