Cholecystokinin-8 vs Hexarelin
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Hexarelin (Growth Hormone Releasing Hexapeptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Hexarelin |
|---|---|---|
| Category | Endocrine Peptides | Performance |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Growth Hormone Releasing Hexapeptide |
| Molecular Weight | 1143.2 Da | 887.04 Da |
| Half-Life | 1-2 min | ~70 minutes |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 6 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 100-200 mcg |
| Route | endogenous secretion|research IV/SC | SC / IV |
| Purity | ≥98% | — |
| Studies Count | 97 | 198 |
| Research Status | Endogenous | Clinical Trials |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Hexarelin Benefits
- ✓Strongest GH pulse among GHRPs
- ✓Cardioprotective effects
- ✓Muscle mass and strength gains
- ✓Fat loss through improved body composition
- ✓Enhanced recovery from training
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Hexarelin Dosing
Standard: 100-200 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100 mcg for overnight GH pulse|Cycle: 8-12 weeks then 4 week break (desensitization)
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Hexarelin Side Effects
- ⚠Common: Increased appetite, water retention, tingling
- ⚠Moderate: Cortisol and prolactin elevation (dose-dependent)
- ⚠Notable: Desensitization occurs after 4-16 weeks of continuous use
- ⚠Rare: Numbness in extremities
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Hexarelin
Hexarelin has extensive pre-clinical and clinical evidence. Multiple human studies confirm potent GH release. Unique cardioprotective properties are well-documented. Note that receptor desensitization limits long-term continuous use.
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