Cholecystokinin-8 vs IGF-1 LR3
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | IGF-1 LR3 |
|---|---|---|
| Category | Endocrine Peptides | Performance |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Insulin-like Growth Factor-1 Long R3 |
| Molecular Weight | 1143.2 Da | 9,117 Da |
| Half-Life | 1-2 min | ~20-30 hours |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 83 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 20-100 mcg |
| Route | endogenous secretion|research IV/SC | IM / SC |
| Purity | ≥98% | — |
| Studies Count | 97 | 298 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
IGF-1 LR3 Benefits
- ✓Promotes muscle hyperplasia (new muscle cells)
- ✓Extended half-life vs native IGF-1
- ✓Enhanced protein synthesis
- ✓Improved nutrient partitioning
- ✓Anti-catabolic effects
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
IGF-1 LR3 Dosing
Standard: 20-50 mcg IM post-workout|Advanced: 50-100 mcg IM or SC daily|Cycle: 4-6 weeks on, 4 weeks off
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
IGF-1 LR3 Side Effects
- ⚠Common: Hypoglycemia (dose-dependent), joint pain, water retention
- ⚠Moderate: Gut growth concern (high doses), acromegaly-like symptoms
- ⚠Serious: Theoretical cancer risk (prolonged high-dose use)
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
IGF-1 LR3
IGF-1 LR3 has extensive in vitro and animal data. Its role in muscle hyperplasia is well-documented. The extended half-life modification provides practical advantages over native IGF-1.
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