Cholecystokinin-8 vs GHRP-6
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and GHRP-6 (Growth Hormone Releasing Peptide-6) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | GHRP-6 |
|---|---|---|
| Category | Endocrine Peptides | Performance |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Growth Hormone Releasing Peptide-6 |
| Molecular Weight | 1143.2 Da | 873.01 Da |
| Half-Life | 1-2 min | ~15-60 minutes |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 6 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 100-300 mcg |
| Route | endogenous secretion|research IV/SC | SC / IV |
| Purity | ≥98% | — |
| Studies Count | 97 | 186 |
| Research Status | Endogenous | Clinical Trials |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
GHRP-6 Benefits
- ✓Potent GH release stimulation
- ✓Muscle growth and strength
- ✓Appetite stimulation (ghrelin pathway)
- ✓Improved body composition
- ✓Enhanced recovery from training
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
GHRP-6 Dosing
Standard: 100-300 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100-200 mcg for overnight GH pulse
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
GHRP-6 Side Effects
- ⚠Common: Increased appetite (significant), water retention, tingling
- ⚠Moderate: Cortisol elevation (dose-dependent), lethargy
- ⚠Rare: Elevated prolactin at high doses
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
GHRP-6
GHRP-6 has solid pre-clinical and clinical evidence for GH stimulation. Well-characterized pharmacology. More appetite stimulation than Ipamorelin due to ghrelin receptor activation.
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