Cholecystokinin-8 vs CJC-1295
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and CJC-1295 (Growth Hormone Releasing Hormone Analog) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | CJC-1295 |
|---|---|---|
| Category | Endocrine Peptides | Performance |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Growth Hormone Releasing Hormone Analog |
| Molecular Weight | 1143.2 Da | 3,367.97 Da |
| Half-Life | 1-2 min | ~6-8 days (DAC) |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 30 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 1-2 mg/week |
| Route | endogenous secretion|research IV/SC | SC |
| Purity | ≥98% | — |
| Studies Count | 97 | 167 |
| Research Status | Endogenous | Clinical Trials |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
CJC-1295 Benefits
- ✓Sustained GH release over days
- ✓Improved body composition
- ✓Enhanced deep sleep quality
- ✓Accelerated recovery from training
- ✓Increased protein synthesis
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
CJC-1295 Dosing
Without DAC: 100-200 mcg SC 2-3 times daily|With DAC: 1-2 mg SC once or twice weekly|Combined with Ipamorelin: 100 mcg each, 2-3x daily
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
CJC-1295 Side Effects
- ⚠Common (Mild): Water retention, tingling/numbness, flushing
- ⚠Moderate: Joint stiffness, carpal tunnel-like symptoms
- ⚠Rare: Elevated blood sugar (transient)
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
CJC-1295
CJC-1295 has good pre-clinical and early clinical data. The DAC variant shows sustained GH elevation for days. Often combined with GHRPs for synergistic GH release.
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