IGF-1 LR3 vs Kisspeptin-10
Head-to-head comparison of IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) and Kisspeptin-10 (Metastin 45-54 (KiSS-1 Fragment)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | IGF-1 LR3 | Kisspeptin-10 |
|---|---|---|
| Category | Performance | Performance |
| Full Name | Insulin-like Growth Factor-1 Long R3 | Metastin 45-54 (KiSS-1 Fragment) |
| Molecular Weight | 9,117 Da | 1,302.41 Da |
| Half-Life | ~20-30 hours | ~4 minutes |
| Amino Acids | 83 | 10 |
| Typical Dose | 20-100 mcg | 100-500 mcg |
| Route | IM / SC | SC / IV |
| Purity | — | — |
| Studies Count | 298 | 156 |
| Research Status | Pre-clinical | Clinical Trials |
IGF-1 LR3 Benefits
- ✓Promotes muscle hyperplasia (new muscle cells)
- ✓Extended half-life vs native IGF-1
- ✓Enhanced protein synthesis
- ✓Improved nutrient partitioning
- ✓Anti-catabolic effects
Kisspeptin-10 Benefits
- ✓Stimulates natural testosterone production
- ✓Activates GnRH release
- ✓Increases LH and FSH
- ✓Does not suppress HPG axis
- ✓May restore fertility
IGF-1 LR3 Dosing
Standard: 20-50 mcg IM post-workout|Advanced: 50-100 mcg IM or SC daily|Cycle: 4-6 weeks on, 4 weeks off
Kisspeptin-10 Dosing
Standard: 100-500 mcg SC daily|Hormone Optimization: 200 mcg SC twice daily|PCT Support: 300 mcg SC daily for 2-4 weeks|Research typically uses IV infusion in clinical settings
IGF-1 LR3 Side Effects
- ⚠Common: Hypoglycemia (dose-dependent), joint pain, water retention
- ⚠Moderate: Gut growth concern (high doses), acromegaly-like symptoms
- ⚠Serious: Theoretical cancer risk (prolonged high-dose use)
Kisspeptin-10 Side Effects
- ⚠Common (Mild): Injection site discomfort, mild flushing
- ⚠Rare: Temporary mood changes, headache
- ⚠Well tolerated in clinical studies
- ⚠Does not cause HPG axis suppression
Research Overview
IGF-1 LR3
IGF-1 LR3 has extensive in vitro and animal data. Its role in muscle hyperplasia is well-documented. The extended half-life modification provides practical advantages over native IGF-1.
Kisspeptin-10
Kisspeptin-10 has growing clinical evidence. Multiple human studies demonstrate reliable GnRH stimulation and subsequent testosterone increase. Being actively studied for reproductive medicine, including IVF protocols and hypogonadism. Unique advantage of not suppressing the HPG axis.
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