IGF-1 LR3 vs Ipamorelin
Head-to-head comparison of IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) and Ipamorelin (Growth Hormone Secretagogue) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | IGF-1 LR3 | Ipamorelin |
|---|---|---|
| Category | Performance | Performance |
| Full Name | Insulin-like Growth Factor-1 Long R3 | Growth Hormone Secretagogue |
| Molecular Weight | 9,117 Da | 711.85 Da |
| Half-Life | ~20-30 hours | ~2 hours |
| Amino Acids | 83 | 5 |
| Typical Dose | 20-100 mcg | 200-300 mcg |
| Route | IM / SC | SC |
| Purity | — | — |
| Studies Count | 298 | 156 |
| Research Status | Pre-clinical | Clinical Trials |
IGF-1 LR3 Benefits
- ✓Promotes muscle hyperplasia (new muscle cells)
- ✓Extended half-life vs native IGF-1
- ✓Enhanced protein synthesis
- ✓Improved nutrient partitioning
- ✓Anti-catabolic effects
Ipamorelin Benefits
- ✓Stimulates natural GH release
- ✓Minimal cortisol/prolactin increase
- ✓Improved body composition
- ✓Enhanced recovery and sleep quality
- ✓Anti-aging effects
IGF-1 LR3 Dosing
Standard: 20-50 mcg IM post-workout|Advanced: 50-100 mcg IM or SC daily|Cycle: 4-6 weeks on, 4 weeks off
Ipamorelin Dosing
Standard: 200-300 mcg SC 2-3 times daily|Pre-bed: 200 mcg SC 30 min before sleep|Combined: 100-200 mcg with CJC-1295 2-3x daily
IGF-1 LR3 Side Effects
- ⚠Common: Hypoglycemia (dose-dependent), joint pain, water retention
- ⚠Moderate: Gut growth concern (high doses), acromegaly-like symptoms
- ⚠Serious: Theoretical cancer risk (prolonged high-dose use)
Ipamorelin Side Effects
- ⚠Common (Mild): Temporary tingling, water retention, increased appetite
- ⚠Rare: Headache, lightheadedness
- ⚠Very Well Tolerated overall
Research Overview
IGF-1 LR3
IGF-1 LR3 has extensive in vitro and animal data. Its role in muscle hyperplasia is well-documented. The extended half-life modification provides practical advantages over native IGF-1.
Ipamorelin
Ipamorelin has moderate clinical evidence. Phase II trials demonstrate selective GH release. Generally regarded as one of the safest GH secretagogues with minimal side effect profile.
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