IGF-1 LR3 vs CJC-1295
Head-to-head comparison of IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) and CJC-1295 (Growth Hormone Releasing Hormone Analog) — benefits, dosing, side effects, research data, and where to buy.
| Property | IGF-1 LR3 | CJC-1295 |
|---|---|---|
| Category | Performance | Performance |
| Full Name | Insulin-like Growth Factor-1 Long R3 | Growth Hormone Releasing Hormone Analog |
| Molecular Weight | 9,117 Da | 3,367.97 Da |
| Half-Life | ~20-30 hours | ~6-8 days (DAC) |
| Amino Acids | 83 | 30 |
| Typical Dose | 20-100 mcg | 1-2 mg/week |
| Route | IM / SC | SC |
| Purity | — | — |
| Studies Count | 298 | 167 |
| Research Status | Pre-clinical | Clinical Trials |
IGF-1 LR3 Benefits
- ✓Promotes muscle hyperplasia (new muscle cells)
- ✓Extended half-life vs native IGF-1
- ✓Enhanced protein synthesis
- ✓Improved nutrient partitioning
- ✓Anti-catabolic effects
CJC-1295 Benefits
- ✓Sustained GH release over days
- ✓Improved body composition
- ✓Enhanced deep sleep quality
- ✓Accelerated recovery from training
- ✓Increased protein synthesis
IGF-1 LR3 Dosing
Standard: 20-50 mcg IM post-workout|Advanced: 50-100 mcg IM or SC daily|Cycle: 4-6 weeks on, 4 weeks off
CJC-1295 Dosing
Without DAC: 100-200 mcg SC 2-3 times daily|With DAC: 1-2 mg SC once or twice weekly|Combined with Ipamorelin: 100 mcg each, 2-3x daily
IGF-1 LR3 Side Effects
- ⚠Common: Hypoglycemia (dose-dependent), joint pain, water retention
- ⚠Moderate: Gut growth concern (high doses), acromegaly-like symptoms
- ⚠Serious: Theoretical cancer risk (prolonged high-dose use)
CJC-1295 Side Effects
- ⚠Common (Mild): Water retention, tingling/numbness, flushing
- ⚠Moderate: Joint stiffness, carpal tunnel-like symptoms
- ⚠Rare: Elevated blood sugar (transient)
Research Overview
IGF-1 LR3
IGF-1 LR3 has extensive in vitro and animal data. Its role in muscle hyperplasia is well-documented. The extended half-life modification provides practical advantages over native IGF-1.
CJC-1295
CJC-1295 has good pre-clinical and early clinical data. The DAC variant shows sustained GH elevation for days. Often combined with GHRPs for synergistic GH release.
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