Kisspeptin-10 vs Hexarelin
Head-to-head comparison of Kisspeptin-10 (Metastin 45-54 (KiSS-1 Fragment)) and Hexarelin (Growth Hormone Releasing Hexapeptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Kisspeptin-10 | Hexarelin |
|---|---|---|
| Category | Performance | Performance |
| Full Name | Metastin 45-54 (KiSS-1 Fragment) | Growth Hormone Releasing Hexapeptide |
| Molecular Weight | 1,302.41 Da | 887.04 Da |
| Half-Life | ~4 minutes | ~70 minutes |
| Amino Acids | 10 | 6 |
| Typical Dose | 100-500 mcg | 100-200 mcg |
| Route | SC / IV | SC / IV |
| Purity | — | — |
| Studies Count | 156 | 198 |
| Research Status | Clinical Trials | Clinical Trials |
Kisspeptin-10 Benefits
- ✓Stimulates natural testosterone production
- ✓Activates GnRH release
- ✓Increases LH and FSH
- ✓Does not suppress HPG axis
- ✓May restore fertility
Hexarelin Benefits
- ✓Strongest GH pulse among GHRPs
- ✓Cardioprotective effects
- ✓Muscle mass and strength gains
- ✓Fat loss through improved body composition
- ✓Enhanced recovery from training
Kisspeptin-10 Dosing
Standard: 100-500 mcg SC daily|Hormone Optimization: 200 mcg SC twice daily|PCT Support: 300 mcg SC daily for 2-4 weeks|Research typically uses IV infusion in clinical settings
Hexarelin Dosing
Standard: 100-200 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100 mcg for overnight GH pulse|Cycle: 8-12 weeks then 4 week break (desensitization)
Kisspeptin-10 Side Effects
- ⚠Common (Mild): Injection site discomfort, mild flushing
- ⚠Rare: Temporary mood changes, headache
- ⚠Well tolerated in clinical studies
- ⚠Does not cause HPG axis suppression
Hexarelin Side Effects
- ⚠Common: Increased appetite, water retention, tingling
- ⚠Moderate: Cortisol and prolactin elevation (dose-dependent)
- ⚠Notable: Desensitization occurs after 4-16 weeks of continuous use
- ⚠Rare: Numbness in extremities
Research Overview
Kisspeptin-10
Kisspeptin-10 has growing clinical evidence. Multiple human studies demonstrate reliable GnRH stimulation and subsequent testosterone increase. Being actively studied for reproductive medicine, including IVF protocols and hypogonadism. Unique advantage of not suppressing the HPG axis.
Hexarelin
Hexarelin has extensive pre-clinical and clinical evidence. Multiple human studies confirm potent GH release. Unique cardioprotective properties are well-documented. Note that receptor desensitization limits long-term continuous use.
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