Kisspeptin-10 vs CJC-1295
Head-to-head comparison of Kisspeptin-10 (Metastin 45-54 (KiSS-1 Fragment)) and CJC-1295 (Growth Hormone Releasing Hormone Analog) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Kisspeptin-10 | CJC-1295 |
|---|---|---|
| Category | Performance | Performance |
| Full Name | Metastin 45-54 (KiSS-1 Fragment) | Growth Hormone Releasing Hormone Analog |
| Molecular Weight | 1,302.41 Da | 3,367.97 Da |
| Half-Life | ~4 minutes | ~6-8 days (DAC) |
| Amino Acids | 10 | 30 |
| Typical Dose | 100-500 mcg | 1-2 mg/week |
| Route | SC / IV | SC |
| Purity | — | — |
| Studies Count | 156 | 167 |
| Research Status | Clinical Trials | Clinical Trials |
Kisspeptin-10 Benefits
- ✓Stimulates natural testosterone production
- ✓Activates GnRH release
- ✓Increases LH and FSH
- ✓Does not suppress HPG axis
- ✓May restore fertility
CJC-1295 Benefits
- ✓Sustained GH release over days
- ✓Improved body composition
- ✓Enhanced deep sleep quality
- ✓Accelerated recovery from training
- ✓Increased protein synthesis
Kisspeptin-10 Dosing
Standard: 100-500 mcg SC daily|Hormone Optimization: 200 mcg SC twice daily|PCT Support: 300 mcg SC daily for 2-4 weeks|Research typically uses IV infusion in clinical settings
CJC-1295 Dosing
Without DAC: 100-200 mcg SC 2-3 times daily|With DAC: 1-2 mg SC once or twice weekly|Combined with Ipamorelin: 100 mcg each, 2-3x daily
Kisspeptin-10 Side Effects
- ⚠Common (Mild): Injection site discomfort, mild flushing
- ⚠Rare: Temporary mood changes, headache
- ⚠Well tolerated in clinical studies
- ⚠Does not cause HPG axis suppression
CJC-1295 Side Effects
- ⚠Common (Mild): Water retention, tingling/numbness, flushing
- ⚠Moderate: Joint stiffness, carpal tunnel-like symptoms
- ⚠Rare: Elevated blood sugar (transient)
Research Overview
Kisspeptin-10
Kisspeptin-10 has growing clinical evidence. Multiple human studies demonstrate reliable GnRH stimulation and subsequent testosterone increase. Being actively studied for reproductive medicine, including IVF protocols and hypogonadism. Unique advantage of not suppressing the HPG axis.
CJC-1295
CJC-1295 has good pre-clinical and early clinical data. The DAC variant shows sustained GH elevation for days. Often combined with GHRPs for synergistic GH release.
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