Hexarelin vs Kisspeptin-10
Head-to-head comparison of Hexarelin (Growth Hormone Releasing Hexapeptide) and Kisspeptin-10 (Metastin 45-54 (KiSS-1 Fragment)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Hexarelin | Kisspeptin-10 |
|---|---|---|
| Category | Performance | Performance |
| Full Name | Growth Hormone Releasing Hexapeptide | Metastin 45-54 (KiSS-1 Fragment) |
| Molecular Weight | 887.04 Da | 1,302.41 Da |
| Half-Life | ~70 minutes | ~4 minutes |
| Amino Acids | 6 | 10 |
| Typical Dose | 100-200 mcg | 100-500 mcg |
| Route | SC / IV | SC / IV |
| Purity | — | — |
| Studies Count | 198 | 156 |
| Research Status | Clinical Trials | Clinical Trials |
Hexarelin Benefits
- ✓Strongest GH pulse among GHRPs
- ✓Cardioprotective effects
- ✓Muscle mass and strength gains
- ✓Fat loss through improved body composition
- ✓Enhanced recovery from training
Kisspeptin-10 Benefits
- ✓Stimulates natural testosterone production
- ✓Activates GnRH release
- ✓Increases LH and FSH
- ✓Does not suppress HPG axis
- ✓May restore fertility
Hexarelin Dosing
Standard: 100-200 mcg SC 2-3 times daily|Pre-workout: 100 mcg 30 min before training|Pre-bed: 100 mcg for overnight GH pulse|Cycle: 8-12 weeks then 4 week break (desensitization)
Kisspeptin-10 Dosing
Standard: 100-500 mcg SC daily|Hormone Optimization: 200 mcg SC twice daily|PCT Support: 300 mcg SC daily for 2-4 weeks|Research typically uses IV infusion in clinical settings
Hexarelin Side Effects
- ⚠Common: Increased appetite, water retention, tingling
- ⚠Moderate: Cortisol and prolactin elevation (dose-dependent)
- ⚠Notable: Desensitization occurs after 4-16 weeks of continuous use
- ⚠Rare: Numbness in extremities
Kisspeptin-10 Side Effects
- ⚠Common (Mild): Injection site discomfort, mild flushing
- ⚠Rare: Temporary mood changes, headache
- ⚠Well tolerated in clinical studies
- ⚠Does not cause HPG axis suppression
Research Overview
Hexarelin
Hexarelin has extensive pre-clinical and clinical evidence. Multiple human studies confirm potent GH release. Unique cardioprotective properties are well-documented. Note that receptor desensitization limits long-term continuous use.
Kisspeptin-10
Kisspeptin-10 has growing clinical evidence. Multiple human studies demonstrate reliable GnRH stimulation and subsequent testosterone increase. Being actively studied for reproductive medicine, including IVF protocols and hypogonadism. Unique advantage of not suppressing the HPG axis.
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