Cholecystokinin-8 vs Glucagon-like peptide-2
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Glucagon-like peptide-2 (Glucagon-like peptide-2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Glucagon-like peptide-2 |
|---|---|---|
| Category | Endocrine Peptides | Gastrointestinal |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Glucagon-like peptide-2 |
| Molecular Weight | 1143.2 Da | ~3.7 kDa |
| Half-Life | 1-2 min | ~7 min |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 33 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | Research-only dosing varies; native peptide is not routinely used clinically |
| Route | endogenous secretion|research IV/SC | SC|IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 90 |
| Research Status | Endogenous | Endogenous |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Glucagon-like peptide-2 Benefits
- ✓mucosal trophic support
- ✓intestinal barrier repair
- ✓nutrient absorption support
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Glucagon-like peptide-2 Dosing
0.5–2 mg/day (research)|SC/IV
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Glucagon-like peptide-2 Side Effects
- ⚠nausea
- ⚠abdominal fullness
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Glucagon-like peptide-2
Native GLP-2 is a key enteric growth factor with rapid degradation by DPP-4. Its therapeutic value is best known through GLP-2 analog development, but the native peptide itself is a real GI-relevant hormone.
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