C-peptide vs Cosyntropin
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and Cosyntropin (Cosyntropin (ACTH 1-24)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | C-peptide | Cosyntropin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Connecting peptide (C-peptide) | Cosyntropin (ACTH 1-24) |
| Molecular Weight | 3020.3 Da | 2933.3 Da |
| Half-Life | ~20-30 min | ~10 min |
| Amino Acids | 31 | 24 |
| Typical Dose | no approved analgesic dose|research-only | 0.25 mg IV/IM diagnostic dose|off-label headache protocols vary |
| Route | IV|subQ | IV|IM |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 61 |
| Research Status | Pre-clinical | Clinical research |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
Cosyntropin Benefits
- ✓refractory migraine
- ✓anti-inflammatory signaling
- ✓headache rescue research
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
Cosyntropin Dosing
0.25 mg IV/IM|1 mg IV/IM
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
Cosyntropin Side Effects
- ⚠flushing
- ⚠nausea
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
Cosyntropin
Cosyntropin is not a standard pain drug, but it appears in headache literature because ACTH analogs can help some patients with difficult migraine attacks. The analgesic rationale is partly tied to steroidogenic and anti-inflammatory effects.
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