Cosyntropin vs Endomorphin-1
Head-to-head comparison of Cosyntropin (Cosyntropin (ACTH 1-24)) and Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cosyntropin | Endomorphin-1 |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Cosyntropin (ACTH 1-24) | Tyr-Pro-Trp-Phe-NH2 |
| Molecular Weight | 2933.3 Da | 610.71 Da |
| Half-Life | ~10 min | Minutes in plasma |
| Amino Acids | 24 | 4 |
| Typical Dose | 0.25 mg IV/IM diagnostic dose|off-label headache protocols vary | 0.1-10 ug per animal |
| Route | IV|IM | Intrathecal / subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 61 | 600 |
| Research Status | Clinical research | Pre-clinical |
Cosyntropin Benefits
- ✓refractory migraine
- ✓anti-inflammatory signaling
- ✓headache rescue research
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Cosyntropin Dosing
0.25 mg IV/IM|1 mg IV/IM
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Cosyntropin Side Effects
- ⚠flushing
- ⚠nausea
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Research Overview
Cosyntropin
Cosyntropin is not a standard pain drug, but it appears in headache literature because ACTH analogs can help some patients with difficult migraine attacks. The analgesic rationale is partly tied to steroidogenic and anti-inflammatory effects.
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
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