Arenicin-1 vs P11-4
Head-to-head comparison of Arenicin-1 (Arenicin-1) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Arenicin-1 | P11-4 |
|---|---|---|
| Category | Marine-Derived | Dental & Oral |
| Full Name | Arenicin-1 | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | 2079 Da | 1466 Da |
| Half-Life | n/a | local activity for hours; peptide degraded over time |
| Amino Acids | 21 | 11 |
| Typical Dose | n/a | 0.5-5 mg per lesion |
| Route | preclinical | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 76 | 40 |
| Research Status | Pre-clinical | Clinical |
Arenicin-1 Benefits
- ✓antimicrobial
- ✓anti-biofilm
- ✓membrane-active
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Arenicin-1 Dosing
bacterial infection|biofilm disruption
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Arenicin-1 Side Effects
- ⚠Arenicola marina
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
Arenicin-1
Marine annelid peptide with strong preclinical antibacterial activity and a stable structural motif that is useful for peptide engineering.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
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