P11-4 vs Piscidin-3
Head-to-head comparison of P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) and Piscidin-3 (Piscidin-3 (hybrid striped bass antimicrobial peptide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | P11-4 | Piscidin-3 |
|---|---|---|
| Category | Dental & Oral | Marine-Derived |
| Full Name | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) | Piscidin-3 (hybrid striped bass antimicrobial peptide) |
| Molecular Weight | 1466 Da | ~2.4 kDa |
| Half-Life | local activity for hours; peptide degraded over time | NR |
| Amino Acids | 11 | 22 |
| Typical Dose | 0.5-5 mg per lesion | NR |
| Route | Topical/Intraoral | in vitro|topical preclinical |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 84 |
| Research Status | Clinical | Pre-clinical |
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Piscidin-3 Benefits
- ✓antibacterial
- ✓anti-biofilm
- ✓host-defense modulation
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Piscidin-3 Dosing
NR|NR
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Piscidin-3 Side Effects
- ⚠hemolysis at high concentrations
- ⚠cytotoxicity risk
- ⚠protease sensitivity
Research Overview
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
Piscidin-3
Preclinical research indicates strong activity against bacterial membranes and drug-resistant strains. Analogs are being evaluated to balance potency with lower toxicity and better stability.
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