Piscidin-3 vs omega-conotoxin MVIIA
Head-to-head comparison of Piscidin-3 (Piscidin-3 (hybrid striped bass antimicrobial peptide)) and omega-conotoxin MVIIA (Ziconotide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Piscidin-3 | omega-conotoxin MVIIA |
|---|---|---|
| Category | Marine-Derived | Marine-Derived |
| Full Name | Piscidin-3 (hybrid striped bass antimicrobial peptide) | Ziconotide |
| Molecular Weight | ~2.4 kDa | 2639 Da |
| Half-Life | NR | 4.5 h (CSF) |
| Amino Acids | 22 | 25 |
| Typical Dose | NR | 1.2 mcg/day initial, titrate as tolerated |
| Route | in vitro|topical preclinical | intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 84 | 78 |
| Research Status | Pre-clinical | Approved |
Piscidin-3 Benefits
- ✓antibacterial
- ✓anti-biofilm
- ✓host-defense modulation
omega-conotoxin MVIIA Benefits
- ✓analgesic
- ✓ion-channel blocker
- ✓neuroactive
Piscidin-3 Dosing
NR|NR
omega-conotoxin MVIIA Dosing
chronic refractory pain|CaV2.2
Piscidin-3 Side Effects
- ⚠hemolysis at high concentrations
- ⚠cytotoxicity risk
- ⚠protease sensitivity
omega-conotoxin MVIIA Side Effects
- ⚠Conus magus
Research Overview
Piscidin-3
Preclinical research indicates strong activity against bacterial membranes and drug-resistant strains. Analogs are being evaluated to balance potency with lower toxicity and better stability.
omega-conotoxin MVIIA
Foundational marine peptide drug; approved as ziconotide for intrathecal treatment of severe chronic pain when other therapies fail.
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Related Comparisons
Common Stacking Partners
Piscidin-3 stacks with:
Piscidin
omega-conotoxin MVIIA stacks with:
Conus magusomega-conotoxinpain
marine-derivedantimicrobial peptidebioactive peptidebioactivecone snailpeptide drug